Toxic effect of using twenty percent alcohol on corneal epithelial tight junctions during LASEK

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Toxic effect of using twenty percent alcohol on corneal epithelial tight junctions during LASEK.

The aim of this study was to determine the effect of using 20% alcohol on corneal epithelial tight junctions during laser epithelial keratomileusis (LASEK). Sixty Sprague-Dawley rats were randomly divided into two equal groups. The central area of the rat corneas in one group were demarcated with a 3-mm trephine, treated with 20% alcohol for 45 sec and washed with sterile balanced salt solution...

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SnapShot: Epithelial Tight Junctions

Tight junctions form a morphological and functional border between the apical and basolateral cell surface domains that serves as a paracellular diffusion barrier, enabling epithelial cells to separate compartments of different composition. Tight junctions also contribute to the generation and maintenance of cell polarity and regulate signaling mechanisms that guide cell behavior, shape, and ge...

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ژورنال

عنوان ژورنال: Molecular Medicine Reports

سال: 2012

ISSN: 1791-2997,1791-3004

DOI: 10.3892/mmr.2012.880